ObjectivesExperiments using P2X3 knock-out mice or more general P2X receptor antagonists suggest that P2X3 receptors contribute to visceral hypersensitivity.We aimed to investigate the effect of the selective P2X3 antagonist A-317491 on visceral sensitivity under physiological conditions, during acute colitis and in the Tamper Seal Fluid post-infla

Cyclic GMP-AMP (cGAMP) synthase (cGAS), a sensor of cytosolic DNA, recognizes cytoplasmic nucleic acids to activate the innate immune responses via generation of the second messenger cGAMP and subsequent activation of the stimulator of interferon genes (STINGs).The cGAS-STING signaling has multiple immunologic and physiological functions in all hum

Introduction: Phyllodes tumors (PTs) of the breast are rare fibroepithelial neoplasms which may be benign, borderline or malignant.Malignant PTs tends to recur more frequently and has the potential to metastasize.Bilateral PT is a rare presentation of the disease.Case presentation: We report a case of 34 years old female patient with bilateral brea

This study aims to analyze and test the influence of job insecurity with job stress as mediation to performance in employees of convenience stores (retail) in Surabaya.The sample was 105 respondents.The data collection tool used is a questionnaire with a copying method using convenience sampling.Hypothesis analysis and testing techniques using PLS-

Cancer cells show a formidable capacity to survive Optical Drive under stringent conditions, to elude mechanisms of control, such as apoptosis, and to resist therapy.Cancer cells reprogram their metabolism to support uncontrolled proliferation and metastatic progression.Phenotypic and functional heterogeneity are hallmarks of cancer cells, which en